HCID 86701442, compound → HCID 86701443, compound

Participants

Reaction Steps

To solution of tert-butyl 4-allyl-5-(difluoromethoxy)-7-methyl-1H-indole-1-carboxylate (2.05 g, 6.08 mmol) in 1,1,1,3,3,3-hexafluoroisopropanol (7.6 mL) was added Pd(OAc)2 (0.041 g, 0.182 mmol) and the reaction stirred for 45 minutes at room temperature. At this point the reaction was concentrated and purified directly by flash chromatography (0-40% EtOAc in heptanes) to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.71 (d, J=4.04 Hz, 1H) 6.87-7.32 (m, 3H) 6.65 (dd, J=16.17, 1.77 Hz, 1H) 6.26-6.43 (m, 1H) 1.94 (dd, J=6.69, 1.64 Hz, 3H) 1.60 (s, 9H).

Provenance & Evidence