Hydrazine hydrate (1:1) → HCID 178514889, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-hydroxy-3-(3-trifluoromethoxyphenylacetyl)-1-(3-trifluoromethylphenyl)-1,8-naphthyridin-2(1H)-one (477 mg, 0.94 mmol) produced in Synthesis Example 18 in DMF (5 mL) was added hydrazine monohydrate (purity of 80%, 184 μL), and the mixture was stirred at 100 to 110° C. for 1 hour. To the reaction solution was added a sodium hydrogencarbonate aqueous solution. The resulting precipitate was separated by filtration, recrystallized from ethanol, and dried to give 3-(3-trifluoromethoxybenzyl)-5-(3-trifluoromethylphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one (241 mg, yield 51%).

Provenance & Evidence