Hydrochloric Acid → HCID 178503112, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of a mixture of (±)-N-((6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)(7-methyl-5-(methylthio)-1-tosyl-1H-indol-4-yl)methyl)-2-methylpropane-2-sulfinamide and (±)-N-((5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)(7-methyl-5-(methylthio)-1-tosyl-1H-indol-4-yl)methyl)-2-methylpropane-2-sulfinamide (1 g, 1.36 mmol), HCl in methanol (1.25 M) (22 mL, 27 mmol) was added and the reaction stirred at 60° C. for 2 h. The reaction was then evaporated, basified with NH4OH (33% NH3 in H2O) and extracted with EtOAc. The organic extract was dried over MgSO4 filtered and concentrated to give the title compound without the need for further purification. MS (ESI+) m/z 502.2 (M+H).

Provenance & Evidence