HCID 86701499, compound → HCID 178429105, compound

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Reaction Steps

A mixture of (±)-tert-butyl 4-(1-(5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxyethyl)-5-(2-methoxy-2-oxoethoxy)-7-methyl-1H-indole-1-carboxylate and (±)-tert-butyl 4-(1-(6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxyethyl)-5-(2-methoxy-2-oxoethoxy)-7-methyl-1H-indole-1-carboxylate was fully deprotected using the same procedure as described in Example 24-B to give the title compound. 1H NMR (TFA salt, 400 MHz, MeOH-d4) δ ppm 8.06 (s, 1H) 7.79 (s, 2H) 7.31 (d, J=3.28 Hz, 1H) 6.92 (d, J=3.28 Hz, 1H) 6.70 (s, 1H) 4.49 (m, 2H) 2.50 (s, 3H) 2.30 (s, 3H). HRMS calcd. for C21H18N4O4 (M+H)+ 391.1401. found 391.1394.

Provenance & Evidence