Hydrazine hydrate (1:1) → HCID 178514880, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 4-hydroxy-1-(3-trifluoromethoxyphenyl)-3-(2-trifluoromethoxyphenylacetyl)-1,8-naphthyridin-2(1H)-one (420 mg, 0.80 mmol) produced in Synthesis Example 23 in DMF (5 mL) was added hydrazine monohydrate (purity of 80%, 155 μL), and the mixture was stirred at 100 to 110° C. for 1 hour. To the reaction solution was added a sodium hydrogencarbonate aqueous solution. The resulting precipitate was separated by filtration, recrystallized from ethanol, and dried to give 3-(2-trifluoromethoxybenzyl)-5-(3-trifluoromethoxyphenyl)-1H-pyrazolo[4,3-c][1,8]naphthyridin-4(5H)-one (233 mg, yield 56%).

Provenance & Evidence