HCID 86701551, compound → HCID 86701552, compound

HRID 2173985Notes

Reaction equation

HRID 2173985 reaction equation
[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:7]=[CH:8][C:9]=1[N+:10]([O-])=O)[C:5]#[N:6]>CO>[NH2:1][C:2]1[C:3]([CH3:13])=[C:4]([CH:7]=[CH:8][C:9]=1[NH2:10])[C:5]#[N:6]

Participants

3

Reactant 1

HCID 86701551HCID 86701551, compound

Product 1

HCID 86701552HCID 86701552, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-amino-2-methyl-4-nitrobenzonitrile (250 mg, 1.41 mmol) in methanol (15 mL), palladium-activated carbon ethylene diamine complex (255 mg, 3.5%-6.5% Pd, 0.071 mmol) was added. The reaction was stirred at rt under hydrogen atmosphere for 2 hr. The catalyst was removed by filtration through Celite® pad. The Celite® pad was washed with MeOH. The collected filtrate was concentrated to give the title compound. MS (ESI+) m/z 148.0 (M+H).

Workup

  1. customThe catalyst was removed by filtration through Celite® pad
  2. washThe Celite® pad was washed with MeOH
  3. concentrationThe collected filtrate was concentrated

Sources & evidence

ORD record
ord-1c98fb0c7d264925a7e0de5c24c5a51c
Source dataset
uspto-grants-2015_06
Patent number
US09056874B2

Reaction notes

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