Boron trifluoride etherate → HCID 178427331, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-((7-methyl-1-tosyl-5-(((2-(trimethylsilyl)ethoxy)methoxy)methyl)-1H-indol-4-yl)methyl)-1H-benzo[d]imidazole-5-carbonitrile (133 mg, 0.221 mmol) in CH2Cl2 (10 mL) was added BF3-OEt2 (0.084 mL, 0.664 mmol) at 0° C. The whole mixture was stirred at 0° C. for 1.5 h, and then at room temperature for 2.5 h. The reaction was quenched by 5% aq. NaHCO3 and stirred for 0.5 h. The layers were separated and the aqueous layer was extracted with CH2Cl2. The organic layers were combined and washed with H2O and brine, dried over Na2SO4, and filtered. Concentration of the filtrate gave the title compound, without need of further purification. MS (ESI+) m/z 471.1 (M+H).

Provenance & Evidence