Phenol → HCID 86701565, compound

HRID 2173995Notes

Reaction equation

HRID 2173995 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:29][OH:30])[C:5]([CH2:21][O:22]C2CCCCO2)=[C:6]2[C:10]=1[N:9]([S:11]([C:14]1[CH:20]=[CH:19][C:17]([CH3:18])=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH:8]=[CH:7]2.[C:31]1(O)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH3:1][C:2]1[C:10]2[N:9]([S:11]([C:14]3[CH:15]=[CH:16][C:17]([CH3:18])=[CH:19][CH:20]=3)(=[O:13])=[O:12])[CH:8]=[CH:7][C:6]=2[C:5]([CH:21]=[O:22])=[C:4]([CH2:29][O:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 996PhenolHCID 86701545HCID 86701545, compound

Product 1

HCID 86701565HCID 86701565, compound

Procedure

The title compound was prepared from (±)-(7-methyl-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-1-tosyl-1H-indol-5-yl)methanol (Example 52-C) using phenol instead of phthalimide in the method depicted in Example 53. MS (ESI+) m/z 420.1 (M+H).

Sources & evidence

ORD record
ord-a15fe65d036046118e38e42572988acd
Source dataset
uspto-grants-2015_06
Patent number
US09056874B2

Reaction notes

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