HCID 86701586, compound → HCID 178435867, compound

Participants

Reaction Steps

The title compounds was synthesized as in Example 25A and 25-B from (±)-2-((5-ethyl-7-methyl-1-tosyl-1H-indol-4-yl)(hydroxy)methyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole-5-carbonitrile and (±)-2-((5-ethyl-7-methyl-1-tosyl-1H-indol-4-yl)(hydroxy)methyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole-6-carbonitrile (Example 70-A). 1H NMR (400 MHz, ACETONITRILE-d3 with about 5 μL TFA) δ ppm 9.42 (br. s., 1H), 8.12 (dd, J=0.76, 1.39 Hz, 1H), 7.79 (dd, J=0.76, 8.59 Hz, 1H), 7.62 (dd, J=1.50, 8.60 Hz, 1H), 7.22 (dd, J=2.90, 3.03 Hz, 1H), 6.99 (s, 1H), 6.06 (dd, J=2.02, 3.03 Hz, 1H), 2.63 (q, J=7.58 Hz, 2H), 2.55 (d, J=0.88 Hz, 3H), 1.14 (t, J=7.58 Hz, 3H). HRMS calcd. for C20H16N4O (M+H)+ 329.1397. found 329.1327.

Provenance & Evidence