HCID 86701641, compound → HCID 178427335, compound

HRID 2174030Notes

Reaction equation

HRID 2174030 reaction equation
[C:1]([C:3]1[CH:49]=[CH:48][C:6]2[N:7](COCC[Si](C)(C)C)[C:8]([C:10]([NH:33][S:34]([C:36]([CH3:39])([CH3:38])[CH3:37])=[O:35])([C:12]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[C:17]4[C:13]=3[CH:14]=[CH:15][N:16]4[S:23]([C:26]3[CH:32]=[CH:31][C:29]([CH3:30])=[CH:28][CH:27]=3)(=[O:25])=[O:24])[CH3:11])=[N:9][C:5]=2[CH:4]=1)#[N:2].C(C1C=CC2N=C(C(NS(C(C)(C)C)=O)(C3C(C)=CC(C)=C4C=3C=CN4S(C3C=CC(C)=CC=3)(=O)=O)C)N(COCC[Si](C)(C)C)C=2C=1)#N>>[C:1]([C:3]1[CH:49]=[CH:48][C:6]2[NH:7][C:8]([C:10]([NH:33][S:34]([C:36]([CH3:38])([CH3:37])[CH3:39])=[O:35])([C:12]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[C:17]4[C:13]=3[CH:14]=[CH:15][N:16]4[S:23]([C:26]3[CH:32]=[CH:31][C:29]([CH3:30])=[CH:28][CH:27]=3)(=[O:25])=[O:24])[CH3:11])=[N:9][C:5]=2[CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 86701641HCID 86701641, compoundHCID 86701642HCID 86701642, compound

Product 1

HCID 178427335HCID 178427335, compound

Procedure

The title compound was synthesized from a mixture of (±)-N-(1-(5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-(5,7-dimethyl-1-tosyl-1H-indol-4-yl)ethyl)-2-methylpropane-2-sulfinamide and (±)-N-(1-(6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-(5,7-dimethyl-1-tosyl-1H-indol-4-yl)ethyl)-2-methylpropane-2-sulfinamide as described in Example 64-B. MS (ESI+) m/z 598.47 (M+H).

Sources & evidence

ORD record
ord-006ac4e187c040fe9077343572faa1b0
Source dataset
uspto-grants-2015_06
Patent number
US09056874B2

Reaction notes

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