Hydrochloric Acid → HCID 178470773, compound

Participants

Reaction Conditions

Reaction Steps

HCl in dioxane (4 M, 2.28 mL, 9.13 mmol) was added to a solution of a mixture of (±)-ethyl 2-(5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-2-(5,7-dimethyl-1-tosyl-1H-indol-4-yl)acetate and (±)-ethyl 2-(6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-2-(5,7-dimethyl-1-tosyl-1H-indol-4-yl)acetate (600 mg, 0.913 mmol) in EtOH (12 mL) at room temperature. The resulting mixture was stirred at 60° C. overnight then partitioned between EtOAc and sat. aq. NaHCO3. The aqueous layer was extracted with EtOAc. The combined organics were washed with brine, dried, and concentrated to give the title compound. The residue was taken onto the next step without further purification. MS (ESI+) m/z 527.3 (M+H).

Provenance & Evidence