N-bromobutanimide → HCID 86701680, compound

Participants

Reaction Steps

To a suspension of 7-bromo-5-methyl-1-tosyl-4-((trimethylsilyl)ethynyl)-1H-indole (70 mg, 0.152 mmol) and AgNO3 (7.75 mg, 0.046 mmol) in acetone (0.8 mL) at 0° C. was added a solution of NBS (38 mg, 0.213 mmol) in acetone (0.8 mL) and the mixture was warmed to room temperature. After stirring overnight the reaction was purified directly by flash chromatography (0-40% EtOAc in heptanes) to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.03 (d, J=3.79 Hz, 1H) 7.72 (d, J=8.59 Hz, 2H) 7.37-7.48 (m, 3H) 6.91 (d, J=3.79 Hz, 1H) 2.38 (s, 3H) 2.37 (s, 3H).

Provenance & Evidence