Isoamylamine → HCID 178426807, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-((7-(hydroxymethyl)-5-methyl-1-tosyl-1H-indol-4-yl)methyl)-1H-benzo[d]imidazole-5-carbonitrile (13 mg, 0.028 mmol), KOH (15.5 mg, 0.276 mmol) and isoamylamine (64 μL, 0.553 mmol) in EtOH (0.8 mL) was stirred at 100° C. using microwave irradiation for 45 minutes. The mixture was directly purified using RP-HPLC (HC-A) to provide the title compound. 1H NMR (TFA salt, 400 MHz, DMSO-d6) δ ppm 10.84 (s, 1H) 7.96 (s, 1H) 7.59 (d, J=8.34 Hz, 1H) 7.45-7.55 (m, 1H) 7.22 (t, J=2.78 Hz, 1H) 6.95 (s, 1H) 6.44-6.51 (m, 1H) 4.74 (s, 2H) 4.47 (s, 2H) 2.39 (s, 3H). HRMS calcd. for C19H16N4O (M+H)+ 317.1402. found 317.1404.

Provenance & Evidence