HCID 86701687, compound → HCID 178437481, compound

Participants

Reaction Conditions

Reaction Steps

A solution of a mixture of 2-(1-(5-ethyl-7-methyl-1-tosyl-1H-indol-4-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole-5-carbonitrile and 2-(1-(5-ethyl-7-methyl-1-tosyl-1H-indol-4-yl)vinyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazole-6-carbonitrile (100 mg, 0.164 mmol) in 1M HCl in MeOH (10 mL) was stirred at 60° C. for 5 h. The reaction mixture was cooled to room temperature. The reaction mixture was diluted with CH2Cl2. The layers were separated and the organic phase was successively washed with 5% aq. NaHCO3, H2O and brine, dried over Na2SO4, and filtered. Concentration of the filtrate gave the title compound, without need of any further purification. MS (ESI+) m/z 481.2 (M+H).

Provenance & Evidence