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HRID2174081

反应详情

EQUATION

反应方程式

HRID 2174081 的结构方程式

REACTANTS

反应物

2
结构：CCO
HCID702

Ethanol

C2H6O

结构：COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(C#N)ccc2o1
HCID86701715

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(C#N)ccc2o1
HCID86701713

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C=O
溶剂HCID280

Carbon dioxide

CO2

PROCEDURE

实验过程

Resolution of the enantiomers of 2-(1-methoxy-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl)benzo[d]oxazole-5-carbonitrile was achieved by chiral SFC using a CHIRALPAK® AD-H column with 60% EtOH (0.2% DEA) in CO2 to give (+)-2-(1-hydroxy-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl)benzo[d]oxazole-5-carbonitrile (tr=6.31 min) and (−)-2-(1-hydroxy-1-(5-methoxy-7-methyl-1H-indol-4-yl)ethyl)benzo[d]oxazole-5-carbonitrile (tr=11.01 min).