Hydrochloric Acid → HCID 178488596, compound

Participants

Reaction Steps

To a solution of a mixture of (±)-tert-butyl 4-(1-(5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-(1,1-dimethylethylsulfinamido)-2,2,2-trifluoroethyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate and (±)-tert-butyl 4-(1-(6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-1-(1,1-dimethylethylsulfinamido)-2,2,2-trifluoroethyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate (Example 36-D) (0.37 g, 0.504 mmol) in dioxane (5.04 mL) was added HCl (4.0M in dioxane) (2.52 mL, 10.08 mmol) and this was stirred at room temperature. After 15 minutes this was cooled in an ice bath, neutralized with 30% aq. NH4OH (2.52 mL), diluted with water, extracted twice with EtOAc, dried with MgSO4, filtered and concentrated. The resulting residue was purified by flash chromatography (0-70% EtOAc in heptanes) to provide the title compound. MS (ESI+) m/z 500.2 (M+H).

Provenance & Evidence