Tin tetrachloride → HCID 178500114, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (±)-tert-butyl 4-(1-(5-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-4-methoxy-4-oxobutyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate and (±)-tert-butyl 4-(1-(6-cyano-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-benzo[d]imidazol-2-yl)-4-methoxy-4-oxobutyl)-5-methoxy-7-methyl-1H-indole-1-carboxylate (Example 146-A) (0.21 g, 0.332 mmol) in DCM (3.32 ml) was added tin(IV) chloride (3.32 ml, 3.32 mmol) at 0° C. The solution was stirred at 0° C. for 30 minutes and then at room temperature for 1 hour. The reaction was concentrated and absorbed onto silica to purify via FCC (0-50% EtOAc:heptanes) to obtain the title compound. MS (ESI+) m/z 403.4 (M+H).

Provenance & Evidence