Potassium Hydroxide → HCID 178489058, compound

Participants

Reaction Steps

(±)-Methyl 4-(5-cyano-1H-benzo[d]imidazol-2-yl)-4-(5-methoxy-7-methyl-1H-indol-4-yl)pentanoate (Example 155-L) (8.5 mg, 0.020 mmol) was dissolved in MeOH (300 μL) and then treated with 10% aq. KOH (70 μl, 0.125 mmol) and stirred at room temperature for 30 minutes. The reaction was directly purified using preparative HPLC (HC-B) to obtain the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.87 (br. s., 1H) 7.92 (br. s.) 7.53 (br. s.) 7.42-7.49 (m) 7.09 (t, J=2.78 Hz, 1H) 6.73 (s, 1H) 5.62 (br. s., 1H) 3.43 (s, 3H) 2.55-2.64 (m, 2H) 2.42 (s, 3H) 1.95-2.05 (m, 2H) 1.88 (s, 3H). MS (ESI+) m/z 403.3 (M+H).

Provenance & Evidence