2-Methyl-2-butene → HCID 86701781, compound

Participants

Reaction Steps

To (±)-tert-butyl 5-methoxy-7-methyl-4-(2-methyl-1-oxopent-4-en-2-yl)-1H-indole-1-carboxylate (Example 156-C) (2 g, 5.60 mmol) in tert-butanol (37.3 mL) and water (18.65 mL) was added 2-methyl-2-butene (5.93 ml, 56.0 mmol), sodium dihydrogen phosphate (2.69 g, 22.38 mmol) and then sodium chlorite (2.53 g, 22.38 mmol). The reaction was allowed to stir at room temperature overnight for 17 hours. At this point the reaction was diluted with EtOAc and water. The layers were separated and the aqueous layer was extracted with EtOAc. The combined organics were dried over MgSO4 and concentrated to obtain the title compound that was use in the next step without further purification. MS (ESI+) m/z 374.3 (M+H).

Provenance & Evidence