Water → HCID 59683713, compound

Participants

Reaction Steps

To 20.0 g of 2,3,5,6-tetrafluorophenol (1) dissolved in 100 mL of MEK there were added 18.3 g of potassium carbonate, 4.26 g of TBAB and 23.7 g of bromoheptane dissolved in 50 mL of MEK, with heating under reflux for 4 hours. After cooling and addition of water, the organic layer was separated and the aqueous layer was extracted with diethyl ether. The organic layers were combined, were washed with saturated brine, and were then dried over anhydrous magnesium sulfate. The solvent was evaporated to yield 31.8 g (120.4 mmol) of 4-heptyloxy-2,3,5,6-tetrafluorobenzene (6).

Provenance & Evidence