Water → HCID 69184975, compound

Participants

Reaction Steps

To 15.0 g of 3,5-difluorophenol (17) dissolved in 100 mL of MEK there were added 17.5 g of potassium carbonate, 4.09 g of TBAB and 24.5 g of bromooctane dissolved in 50 mL of MEK, with heating under reflux for 4 hours. After cooling and addition of water, the organic layer was separated and the aqueous layer was extracted with diethyl ether. The organic layers were combined, were washed with saturated brine, and were then dried over anhydrous magnesium sulfate. After evaporating the solvent there were obtained 27.9 g (115 mmol) of 3,5-difluorooctyloxybenzene (18).

Provenance & Evidence