Potassium Carbonate → HCID 131732977, compound

Participants

Reaction Steps

A suspension of 1-[2-(3-pyridyl)thiazol-5-yl]ethanone (0.8 g, 3.76 mmol) in 50 ml EtOH was treated with hydroxylamine hydrochloride (0.277 g, 3.95 mmol) and potassium carbonate (0.551 g, 3.95 mmol), and stirred at ambient temperature, monitored by LCMS and TLC, which indicated a ca. 1:1 mixture of isomer formation. After 3 hours, the mixture was concentrated in vacuo to approximately 10 ml. Addition of saturated ammonium chloride gave Isomer A of the title product as a beige precipitate which was filtered, and washed successively with water, isopropanol, and tertiary-butyl methyl ether (yield 156 mg).

Provenance & Evidence