Carbonate Ion → HCID 123842023, compound

Participants

Reaction Steps

A suspension of 1-[2-(3-pyridyl)thiazol-5-yl]ethanone oxime (isomer A, 0.15 g, 0.657 mmol) in acetonitrile (5 ml) was stirred at ambient temperature and treated with carbonate (0.648 g, 1.97 mmol) and 2-chloropyrimidine (0.119 g, 0.985 mmol) and allowed to stir at ambient temperature. After 2 days (80% conversion), the reaction mixture was concentrated in vacuo and the residue was stirred with ethyl acetate, filtered and the ethyl acetate concentrated in vacuo. Purification by flash chromatography eluting with ethyl acetate gave 1-[2-(3-pyridyl)thiazol-5-yl]-N-pyrimidin-2-yloxy-ethanimine (0.074 g, 38%) as a single isomer as slightly yellow crystals.

Provenance & Evidence