Cesium carbonate → HCID 123842023, compound

Participants

Reaction Steps

A suspension of 1-[2-(3-pyridyl)thiazol-5-yl]ethanone oxime (76 mg, 0.33 mmol) and cesium carbonate (330 mg, 1.0 mmol) in acetonitrile (10 ml) was stirred at ambient temperature and treated with 2-chlopyrimidine (60 mg, 0.5 mmol). The reaction was monitored by TLC and LC/MS until ca. 70% completion, and then concentrated in vacuo. The solid residue was stirred with ethyl acetate, filtered and concentrated in vacuo. The crude product was purified by flash chromatography, eluting with ethyl acetate:MeOH (95:5), to give isomer B of 1-[2-(3-pyridyl)thiazol-5-yl]-N-pyrimidin-2-yloxy-ethanimine (46 mg, 46%) as white crystals.

Provenance & Evidence