Water → HCID 86712392, compound

Participants

Reaction Conditions

Reaction Steps

4.9 g of 8-fluoro-3-hydroxy-2-methylquinoline, 3.2 g of 3-chloro-2-cyanopyridine and 3.8 g of potassium carbonate were dissolved in 20 ml of N-methylpyrrolidone followed by stirring for 3 hours at 130° C. Subsequently, the reaction solution was cooled to room temperature followed by addition of water and extraction with ethyl acetate. The extract was washed with saturated saline and dried with magnesium sulfate followed by distilling off the solvent under reduced pressure. The resulting residue was purified by silica gel column chromatography to obtain 5.37 g of 3-(2-cyano-pyridin-3-yloxy)-8-fluoro-2-methylquinoline.

Provenance & Evidence