Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,2,6,6-Tetramethyl-3,5-heptanedione | HCID 70700 | — |
| Reactant | 8-fluoroquinolin-3-ol | HCID 68288067 | — |
| Reactant | 1415018-68-6 | HCID 86712398 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 86712397 | HCID 86712397 | 29.8% |
Reaction Steps
1.35 g of 2-(3-bromo-pyridin-2-yl)-2-methyl-propionitrile were dissolved in 6 ml of N-methylpyrrolidone. 0.82 g of 8-fluoro-3-hydroxyquinoline, 1.95 g of cesium carbonate, 0.18 g of dipivaloylmethane and 0.50 g of copper (I) chloride were added thereto followed by stirring for 23 hours at 130° C. Subsequently, the reaction mixture was cooled to room temperature and purified by silica gel column chromatography to obtain 0.46 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09060517B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-4c258d31203c4d7f84cbdb1dd6ceb4db |
|---|
| Source note | uspto-grants-2015_06 |
|---|
