Ethanol → HCID 86712399, compound

Participants

Reaction Conditions

Reaction Steps

2 ml of ethanol and 2 ml of concentrated sulfuric acid were added to 0.38 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionitrile. The mixture was stirred for 6 hours at 100° C. Subsequently, saturated aqueous sodium hydrogen carbonate solution was added thereto to stop the reaction. The resultant was then extracted with ethyl acetate followed by distilling off the solvent of the organic layer. Subsequently, the resultant was purified by silica gel column chromatography to obtain 0.24 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methylpropionic acid ethyl ester.

Provenance & Evidence