Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2,2,6,6-Tetramethyl-3,5-heptanedione | HCID 70700 | — |
| Reactant | 8-fluoroquinolin-3-ol | HCID 68288067 | — |
| Reactant | HCID 86712401 | HCID 86712401 | — |
| Catalyst | Cuprous chloride | HCID 62652 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 86712402 | HCID 86712402 | 34.1% |
Reaction Steps
0.41 g of 2-(3-bromo-pyridin-2-yl)-2-methyl-propioaldehyde were dissolved in 4 ml of N-methylpyrrolidone. 0.59 g of 8-fluoro-3-hydroxyquinoline, 1.2 g of cesium carbonate, 0.07 g of dipivaloylmethane and 0.18 g of copper (I) chloride were added thereto followed by stirring for 16 hours at 130° C. Subsequently, the reaction solution was cooled to room temperature and purified by silica gel column chromatography to obtain 0.19 g of 2-[3-(8-fluoro-quinolin-3-yloxy)-pyridin-2-yl]-2-methyl-propioaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09060517B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-eadc2c79f80849ab90c59f73ca1314f0 |
|---|
| Source note | uspto-grants-2015_06 |
|---|
