4-tert-Butylphenol → 4-tert-Butylcyclohexanol

Participants

Reaction Steps

U.S. Pat. No. 2,927,127 discloses that hydrogenation of p-tert-butyl phenol with a Ni catalyst yields p-tert-butyl cyclohexanol having proportions of approximately 30% cis-isomer and approximately 70% trans-isomer. U.S. Pat. No. 2,927,127 further describes the hydrogenation of p-tert-butyl phenol using Rh/C as catalyst in ethanol to yield p-tert-butyl cyclohexanol containing 87.5% of the cis-isomer, which was subsequently converted to the corresponding acetates by reaction with acetic anhydride.

Provenance & Evidence