Dimethylformamide → HCID 69093847, compound

Participants

Reaction Steps

To a stirring solution of 3-(3-(pyridin-2-yl)-1H-1,2,4-triazol-5-yl)isoxazole hydrochloride (1 eq) in DMF was added sodium hydride (2.1 eq). After 10 minutes, 1-(bromomethyl)-2-fluorobenzene (1.1 eq) was added and the reaction was stirred overnight at room temperature. Brine was used to quench the reaction. Methylene chloride was used to extract the aqueous layer. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated. SiO2 chromatography yielded 3-(1-(2-fluorobenzyl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-yl)isoxazole in 13.5% yield as a solid and 3-(1-(2-fluorobenzyl)-3-(pyrimidin-2-yl)-1H-1,2,4-triazol-5-yl)isoxazole in 15.7% yield as a solid.

Provenance & Evidence