Potassium Cyanide → HCID 69093841, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(5-bromo-1-(2-fluorobenzyl)-1H-1,2,4-triazol-3-yl)pyridine (I-16, 0.95 g, 2.9 mmol) in N,N-dimethylformamide (9.5 mL) was added potassium cyanide (0.928 g, 14.3 mmol). After heating the solution at 100° C. for 22 h, the solution was diluted with ethyl acetate (125 mL) and water (100 mL). The layers were separated, and the aqueous layer was extracted with ethyl acetate (2×50 mL). The organics were combined, washed with water (50 mL) and brine (50 mL), dried over magnesium sulfate, filtered, and the solvent was removed in vacuo to give the crude product as an orange oil. Purification by silica gel chromatography (0-15% ethyl acetate in dichloromethane) gave 1-(2-fluorobenzyl)-3-(pyridin-2-yl)-1H-1,2,4-triazole-5-carbonitrile, I-33 (250 mg, 0.90 mmol, 31% yield) as a white solid.

Provenance & Evidence