反应详情

A solution of ethyl 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxylate (Intermediate-3, 0.78 mmol) and sodium cyanide (0.1 equiv) in ammonia/MeOH (7N, 30 equiv, 3.4 mL) in a seal tube was heated at 90° C. for 24 h. The reaction mixture was cooled to room temperature, conc. and dried in vacuo to afford 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboxamide as a tan solid (>99% yield).

1. customconc. and dried in vacuo