HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2174293Generated: October 30, 2026
2-(2-Phenyldiazenyl)propanedinitrile → 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine
https://huagongshe.com/reaction/2174293
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-(2-Phenyldiazenyl)propanedinitrile | HCID 22347 | — |
| Reactant | 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide | HCID 69094296 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine | HCID 69094074 | 99% |
Reaction Steps
A suspension of 1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazole-3-carboximidamide (Intermediate-6, 0.38 mmol) and 2-(phenyldiazenyl)malononitrile (1 equiv) in ethanol (6 mL) in a sealed tube was heated at 110° C. for 2 h. The reaction was conc. to afford 2-(1-(2-fluorobenzyl)-5-(thiazol-2-yl)-1H-1,2,4-triazol-3-yl)-5-(phenyldiazenyl)pyrimidine-4,6-diamine as an orange solid (>99% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09061030B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-39917d0df3a64197bc0d1c20a9715588 |
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| Source note | uspto-grants-2015_06 |
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