Lithium hydroxide, monohydrate → HCID 59235360, compound

Participants

Reaction Steps

To a solution of (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(4-acetylbenzyl)-4-chlorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate (95 mg, 0.17 mmol) in a mixture of tetrahydrofuran/methanol/water (2.4 mL, 2:3:1) was added lithium hydroxide monohydrate (11.2 mg, 0.27 mmol). After stirring overnight at RT, volatiles were removed under reduced pressure. The residue was partitioned between water and ethyl acetate (3×), and the combined organic phases were washed with brine, dried over sodium sulfate, and concentrated to give crude product 48 (68 mg), which was used in the next step without further purification. MS ESI: 407 [M+H]+, 451 [M+HCO2]−.

Provenance & Evidence