反应详情

To a solution of 4-fluoro-2-(trifluoromethyl)benzoic acid in MeOH were added concentrated sulfuric acid at 0° C. The reaction mixture was heated and refluxed for 2 days. The reaction mixture was concentrated under reduced pressure and the residue was diluted with EtOAc. The organic layer was washed with a saturated aqueous NaHCO3 solution, dried over MgSO4, and then concentrated under reduced pressure to obtain methyl 4-fluoro-2-(trifluoromethyl)benzoate as a colorless oily substance.

1. temperatureThe reaction mixture was heated
2. temperaturerefluxed for 2 days
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. additionthe residue was diluted with EtOAc
5. washThe organic layer was washed with a saturated aqueous NaHCO3 solution
6. dry with materialdried over MgSO4
7. concentrationconcentrated under reduced pressure