Hydrochloric Acid → HCID 86090158, compound

Participants

Reaction Conditions

Reaction Steps

To 16-bromohexadecanoic acid methyl ester (1.40 g, 4.0 mmol) in MeCN (20 ml) were added malonodinitrile (1.01 g, 15.3 mmol) and K2CO3 (0.92 g, 6.64 mmol). The mixture was stirred at 80° C. for 18.5 h. Water (50 ml) and 1N HCl (50 ml) were added, and the product was extracted with AcOEt. The combined extracts were washed with brine, dried over MgSO4, and concentrated under reduced pressure. 1.87 g (100%) of an oil was obtained which crystallized completely after some hours.

Provenance & Evidence