HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 217444Generated: October 26, 2026
Water → 7-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2H-chromene-3-carbaldehyde
https://huagongshe.com/reaction/217444
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4-Bis(trifluoromethyl)benzyl bromide | HCID 518871 | — |
| Reactant | 7-Hydroxy-2H-chromene-3-carbaldehyde | HCID 16769166 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2H-chromene-3-carbaldehyde | HCID 86657641 | — |
Reaction Steps
7-Hydroxy-2H-chromene-3-carbaldehyde (200 mg) was dissolved in DMF (5 mL), and K2CO3 (235 mg) and 1-(bromomethyl)-2,4-bis(trifluoromethyl)benzene (0.234 mL) were added thereto, followed by stirring at 80° C. for 30 minutes. The reaction liquid was poured into water, and the resulting powder was collected by filtration and dried under reduced pressure to obtain 7-{[2,4-bis(trifluoromethyl)benzyl]oxy}-2H-chromene-3-carbaldehyde (455 mg) as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08193378B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-bb615ba9c64f4c8c80c17cc037fc6111 |
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| Source note | uspto-grants-2012_06 |
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