HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 217446Generated: October 25, 2026
[(4-Isobutylphenyl)ethynyl](trimethyl)silane → 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde
https://huagongshe.com/reaction/217446
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | [(4-Isobutylphenyl)ethynyl](trimethyl)silane | HCID 58438693 | — |
| Reactant | 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate | HCID 86657642 | — |
| Catalyst | Cupric Chloride | HCID 24014 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Fluoro-7-((4-isobutylphenyl)ethynyl)-2H-chromene-3-carbaldehyde | HCID 58438685 | 23.8% |
Reaction Steps
To a solution of copper chloride (10 mg) and Pd(PPh3)4 (60 mg) in DMF (2 mL) were added [(4-isobutylphenyl)ethynyl](trimethyl)silane (288 mg) and 5-fluoro-3-formyl-2H-chromen-7-yl trifluoromethanesulfonate (340 mg) at room temperature, followed by stirring at 80° C. for 12 hours. The reaction liquid was concentrated and the residue was purified by silica gel column chromatography (CHCl3) to obtain 5-fluoro-7-[(4-isobutylphenyl)ethynyl]-2H-chromene-3-carbaldehyde (83 mg) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08193378B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-2d1d4fcb25d646269e27f1f81a42f442 |
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| Source note | uspto-grants-2012_06 |
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