Phosphorus oxychloride → HCID 86698898, compound

Participants

Reaction Conditions

Reaction Steps

8-chloro-5-(2-morpholinoethoxy)quinolin-2(1H)-one (200 mg, 0.6 mmol, 1 eq.) was placed in acetonitrile (1.7 mL) in the presence of POCl3 (301 μL, 3.2 mmol, 5 eq.) and triethylammonium chloride (738 mg, 3.2 mmol, 5 eq.). The reaction mixture was stirred at 120° C. for 3 hours. The mixture was then concentrated under reduced pressure and, after adding water to the residue (5 mL), was stirred at room temperature during 30 minutes. Then the resulting precipitate was washed with water and filtered to give 4-(2-((2,8-dichloroquinolin-5-yl)oxy)ethyl)morpholine (234 mg, 100%).

Provenance & Evidence