HCID 58438971, compound → HCID 58438730, compound

HRID 217451Notes

Reaction equation

HRID 217451 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([C:14]([O:16][CH3:17])=[O:15])[S:10][C:11]=2[CH:12]=[CH2:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCO.[Pd]>[CH2:12]([C:11]1[S:10][C:9]([C:14]([O:16][CH3:17])=[O:15])=[CH:8][C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:13]

Participants

4

Reactant 1

HCID 58438971HCID 58438971, compound

Product 1

HCID 58438730HCID 58438730, compoundYield 98.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

At a normal pressure under a hydrogen gas atmosphere, to a solution of methyl 4-phenyl-5-vinylthiophene-2-carboxylate (250 mg) in EtOH (5 mL) was added Pd/C (50% wet) (50 mg) at 25° C., followed by stirring for 5 hours. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to obtain methyl 5-ethyl-4-phenylthiophene-2-carboxylate (247.3 mg) as a colorless liquid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-c39c80b2f9024be8a743370c50dfe707
Source dataset
uspto-grants-2012_06
Patent number
US08193378B2

Reaction notes

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