HCID 15157644, compound → HCID 100304374, compound

Participants

Reaction Steps

This compound was prepared from 408b (263 mg, 1.39 mmol) in a manner similar to that for 409a except for after the drop-wise addition of substituted indole, the solution was stirred for 1 h. A cream-colored powder was obtained (228 mg, 75%): mp 156-158° C. TLC Rf 0.52 (75% EtOAc/hexanes). 1H NMR (600 MHz, d6-DMSO) δ 11.85 (s, 1H), 10.00 (s, 1H), 7.55 (d, 1H, J=2.46 Hz), 7.27-7.25 (d, 1H, J=8.7 Hz), 6.79-6.77 (dd, 1H, J1=8.7 Hz, J2=2.52 Hz), 3.92-3.90 (t, 2H, J=6.54 Hz), 2.64 (s, 3H), 1.77-1.71 (sex, 2H, J=7.38 Hz), 1.00-0.98 (t, 3H, J=7.38 Hz). NMR (150 MHz, d6-DMSO) δ 184.0, 154.9, 148.5, 130.0, 126.4, 113.6, 112.26, 112.04, 103.2, 69.3, 22.2, 11.5, 10.5. Elemental analysis calculated for C13H15NO2: C, 71.87; H, 6.96; N, 6.45. Found: C, 71.74; H, 6.81; N, 6.42.

Provenance & Evidence