HCID 68244627, compound → HCID 118108312, compound

Participants

Reaction Steps

This compound was prepared from 408d (300 mg, 1.48 mmol) in a manner similar to that for 409b to yield a cream-colored powder (320 mg, 94%): mp 160-161° C. TLC Rf 0.45 (3:1 EtOAc/hexanes). 1H NMR (600 MHz, d6-DMSO) δ 11.85 (s, 1H), 10.00 (s, 1H), 7.55 (d, 1H, J=2.46 Hz), 7.26-7.25 (d, 1H, J=8.7 Hz), 6.79-6.77 (dd, 1H, J1=8.7 Hz, J2=2.46 Hz), 3.96-3.94 (t, 2H, J=6.48 Hz), 2.64 (s, 3H), 1.73-1.68 (quin, 2H, J=6.48 Hz), 1.49-1.42 (sex, 2H, J=7.38 Hz), 0.95-0.93 (t, 3H, J=7.38 Hz). 13C NMR (150 MHz, d6-DMSO) δ 185.0, 154.9, 148.5, 130.0, 126.4, 113.6, 112.26, 112.04, 103.2, 67.4, 31.0, 18.8, 13.8, 11.5. Elemental analysis calculated for C14H17NO2: C, 72.70; H, 7.41; N, 6.06. Found: C, 72.87; H, 7.47; N, 6.13.

Provenance & Evidence