Hydrochloric Acid → HCID 86706570, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-{4-[4-(7-chloro-4-hydroxy-2-oxo-3-phenyl-1,2-dihydro-6-quinolinyl)phenyl]-1,3-thiazol-2-yl}acetamide (Example 9) (1.7 g, 3.81 mmol) in ethanol (20 mL) was added concentrated hydrochloric acid (5.72 mL, 57.2 mmol) and the reaction mixture was stirred at 100° C. for 4 h. After cooling, the reaction mixture was filtered. The solid was washed with water and dried under reduced pressure to give the title compound 6-[4-(2-amino-1,3-thiazol-4-yl)phenyl]-7-chloro-4-hydroxy-3-phenylquinolin-2(1H)-one hydrochloride (1.45 g, 3.01 mmol, 79% yield) as a grey powder. LCMS: (M+H)+=446; Rt=2.44 min. HRMS calculated for C24H15ClN3O2S (M−H)+: 444.0574. found: 444.0532.

Provenance & Evidence