反应详情

温度

80 °C

7-(Methoxymethoxy)-2,2-dimethyl-2H-chromene-3-carbaldehyde (300 mg) was dissolved in EtOH (10 mL), and (1S)-(+)-10-camphor sulfonic acid (421 mg) was added thereto, followed by stirring at 80° C. overnight. To the reaction liquid was added silica gel, followed by concentration. The residue was purified by silica gel column chromatography (automatic purification device, hexane:EtOAc=90:10 to 70:30) to obtain 7-hydroxy-2,2-dimethyl-2H-chromene-3-carbaldehyde (175 mg) as a red powder.

1. customTo the reaction liquid
2. additionwas added silica gel
3. concentrationfollowed by concentration
4. customThe residue was purified by silica gel column chromatography (automatic purification device, hexane:EtOAc=90:10 to 70:30)