HCID 117690725, compound → HCID 89610028, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3b (260 mg, 0.81 mmol) in methanol (5 ml) was added 10% Pd/C (130 mg). The mixture was degassed with nitrogen for 10 minutes and continued stirring at 20-35° C. under H2 gas atmosphere for 3 h. The progress of the reaction was monitored by TLC. The reaction mixture was filtered on celite bed, celite bed washed with methanol and resultant filtrate concentrated to get the desired product as a yellow waxy solid (180 mg, 96%). 1H NMR (400 MHz, DMSO-d6) δ 7.52 (dd, J=6.8, 2.0 Hz, 1H), 7.47-7.44 (m, 1H), 7.26-7.18 (m, 2H), 5.20 (bs, 1H), 2.92 (s, 1H), 2.73 (d, J=10.7 Hz, 2H), 2.44 (t, J=10.5 Hz, 2H), 2.34 (s, 3H), 2.15-2.07 (m, 2H), 1.84 (d, J=12.7 Hz, 2H); MS (ES) m/e 232.1 (M+H)+.

Provenance & Evidence