Methanol → AGN-PC-008D8H
Reaction equation
Cl[CH2:2][CH:3]([OH:12])[CH2:4][S:5][S:6][CH2:7][CH:8]([OH:11])[CH2:9]Cl.CO.[OH-].[Na+]>C1(C)C=CC=CC=1>[O:11]1[CH2:9][CH:8]1[CH2:7][S:6][S:5][CH2:4][CH:3]1[O:12][CH2:2]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 5 °C
Procedure
Next, a mixed solution of bis(3-chloro-2-hydroxypropyl)disulfide described above and 250 g of methanol was dripped into a reaction vessel containing a mixed solvent consisting of 500 g of toluene and 240 g of 47% aqueous solution of sodium hydroxide with the temperature of the solution in the reaction vessel being maintained at 0 to 10° C. At the point of the completion, no scum-like insoluble matter was generated. 100 g of toluene was added to carry out extraction, the aqueous layer was removed, and the organic layer was washed with 180 g of water three times. After that, no scum-like insoluble matter was generated. After that, the solvent was distilled away, thereby obtaining 171 g of bis(β-epoxypropyl)disulfide.
Workup
- customwas dripped into a reaction vessel
- additioncontaining a mixed solvent
- extractionextraction
- customthe aqueous layer was removed
- washthe organic layer was washed with 180 g of water three times
- distillationAfter that, the solvent was distilled away
Sources & evidence
- ORD record
- ord-3b85f5e7914b4a4abe7165d57f8b7eb6
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09062016B2
Reaction notes
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