2-Chloro-4-trifluoromethylaniline → HCID 86709744, compound

Participants

Reaction Steps

trans-2-Phenylspiro[2.4]heptane-1-carboxylic acid (300 mg, 1.39 mmol) and 2-chloro-4-trifluoromethyl-phenylamine (272 mg, 1.39 mmol) were reacted as described under General Procedure D to furnish the title compound (312 mg, 57%) as a white solid. 1H NMR (300 MHz, d6-DMSO) δ 9.91 (s, 1H), 8.20 (d, J=8.5 Hz, 1H), 7.89 (d, J=1.6 Hz, 1H), 7.67 (d, J=8.5, 1.6 Hz, 1H), 7.31 (t, J=7.3 Hz, 2H), 7.22-7.16 (m, 3H), 2.80 (d, J=5.7 Hz, 1H), 2.70 (d, J=5.7 Hz, 1H), 1.82-1.73 (m, 2H), 1.66-1.42 (m, 5H), 1.29-1.10 (m, 1H). mp 131-133° C. ESIMS m/z [M+H]+ 394.3.

Provenance & Evidence