2,2-Difluoro-5-formylbenzodioxole → HCID 68280102, compound

Participants

Reaction Steps

2,2-difluoro-1,3-benzodioxole-5-carboxaldehyde (5.0 g, 26.9 mmol) and mono-ethyl malonate (4.1 ml, 34.9 mmol) were reacted as described under General Procedure A to furnish the title compound (5.6 g, 82%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 7.61 (d, J=16.0 Hz, 1H), 7.26-7.22 (m, 2H), 7.06 (d, J=7.9 Hz, 1H), 6.33 (d, J=16.0 Hz, 1H), 4.26 (q, J=7.1 Hz, 2H), 1.33 (t, J=7.1 Hz, 3H).

Provenance & Evidence