Ethylenediamine → HCID 67067110, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Bromobenzoyl)quinoline (10.30 g, 33.0 mmol) was added to 100 mL of ethylene diamine, followed by stirring at 100° C. for 18 hours. Then the resulting reaction solution was cooled to room temperature, and poured into brine, followed by extracting with ethyl acetate. The organic layer was washed with brine twice, followed by drying with magnesium sulfate. The solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: chloroform:methanol=9:1) to obtain the target compound (1.19 g, yield: 13%).

Provenance & Evidence