Water → HCID 68109186, compound

Participants

Reaction Conditions

Reaction Steps

2,3-Dihydro-5-(3-quinolinyl)-1H-1,4-benzodiazepine (0.12 g, 0.44 mmol) was dissolved in 5 mL of dimethyl formamide, and added with isopropyl iodide (0.11 g, 0.65 mmol) and potassium carbonate (0.10 g, 0.72 mmol), followed by stirring at 100° C. for 48 hours. Isopropyl iodide (0.22 g, 1.29 mmol) and potassium carbonate (0.20 g, 1.45 mmol) were added to the resulting reaction solution, followed by stirring at 100° C. for 14 hours. The resulting reaction solution was cooled to room temperature, and cold water was poured into the reaction solution, followed by extracting with ethyl acetate. The organic layer was washed with brine, followed by drying magnesium sulfate. The solvent was distilled off under reduced pressure. The resulting residue was purified by silica gel column chromatography (chloroform:ethyl acetate=7:3) to obtain the target compound (0.012 g, yield: 8.7%).

Provenance & Evidence